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HERA JournalSkin boosters

Rejuran Korean Skincare in a Jar vs Rejuran in a Syringe

Dr. Kim Jong SeonDr. Kim Jong Seon · Filler Specialist8 min read
Medically reviewed by Dr. Kim Jong Seon · Director, Gangnam HERA Plastic Surgery ClinicEdited by Dr. Kim Jong Seon
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The surprising part for most visitors is that the Rejuran on Seoul drugstore shelves and the Rejuran a doctor injects are two separate product lines under one Korean brand. Both are built around polynucleotides (PN) from purified salmon DNA. A serum or cream works on the skin's surface; the injection places PN into the dermis with a fine needle. So a search for "Rejuran Korean skincare" really covers a cosmetics purchase and a medical treatment that happen to share a name.

If you're fitting this into a short trip, somewhere between a shopping afternoon and the flight home, the useful question is which of the two matches what you want to change. The terms below are grouped the way you'll meet them: on the box, in the consult room, and in the mirror over the following week.

The words on the box: PN, PDRN and "salmon"

PN, short for polynucleotides, are long chains of DNA fragments; in Rejuran's case they are purified from salmon. PDRN (polydeoxyribonucleotide) is a related molecule made of shorter fragments, and the two names often get used as if they meant the same thing.

  • Polynucleotide (PN). The ingredient Rejuran is known for. A 2025 review in Pharmaceutics comparing PN and PDRN explains that chain length changes how the molecule behaves: PN's longer chains hold water and give a more gel-like quality in tissue, which is part of why PN is used for skin quality rather than volume.
  • PDRN. The shorter-fragment cousin, studied mainly for tissue repair; a 2021 review in Pharmaceuticals summarises its research in impaired wound healing. A label that says "PDRN" isn't automatically describing Rejuran's PN.
  • "Salmon injection." A nickname, not a description. It refers to where the DNA is sourced, and the material is purified before it goes into any product.
  • Serum, ampoule, cream. Cosmetic formats sold over the counter. Their labels talk about hydration, soothing and barrier care.

Does a Rejuran serum do what the injection does?

No. A topical product is designed to act on the outer layers of skin, while the injection delivers PN into the dermis, which is where clinical studies of injectable polynucleotides look for changes in texture, elasticity and hydration.

Part of the reason is size. A widely cited paper in Experimental Dermatology (Bos and Meinardi, 2000) proposed the "500 Dalton rule": compounds much larger than about 500 daltons pass poorly through healthy, intact skin. Polynucleotide chains are far larger than that.

That doesn't make the serum pointless. A well-made one can hydrate and calm skin the way a good moisturiser does. It means the jar and the syringe are different tools, not a weak and a strong version of the same thing.

Rejuran serum or creamRejuran injection
Where it worksSurface and upper skin layersDermis, placed by needle
Who applies itYou, at homeA doctor, in a clinic
Typical useDaily, as part of a routineSessions spaced weeks apart, planned by the doctor
What to expectHydration and comfortGradual change in texture and fine lines, varies by person
Marks afterwardNoneSmall bumps, possible redness or bruising

Worth knowing

Buying the cosmetic line in Seoul needs no consultation. The injection is a medical procedure, and the doctor decides whether it's appropriate for your skin.

What do HB, I and "Healer" mean on a Rejuran menu?

HB, I and Healer are names for versions of the injectable. HERA's Rejuran treatment page lists three: Rejuran, Rejuran HB and Rejuran I. The version is chosen for the area and the concern, not for the name.

  • Rejuran (often searched as "Rejuran Healer"). The original PN injectable, used across the face for texture, fine lines and dullness.
  • Rejuran HB. Commonly described as PN combined with hyaluronic acid and a local anaesthetic, which makes the injections feel smoother for many people.
  • Rejuran I. Made for the thin skin around the eyes, where fine crepey lines show first.
  • Rejuran S. A name that comes up in searches, usually linked with scars. It isn't among the versions on HERA's treatment page.
  • Skin booster. The umbrella term for injectables aimed at skin quality rather than volume. On HERA's menu, Rejuran sits next to Juvelook, a PDLLA collagen-stimulating booster, and Potenza Exosome, which pairs RF microneedling with an exosome booster.

The choice depends on what the doctor sees in person. Thin under-eye skin with vessels close to the surface carries more bruising risk and calls for a different version and technique from the cheeks. Enlarged pores with uneven texture may point toward microneedling instead of, or alongside, an injection. Hollowness that comes from lost volume isn't something PN corrects; that is a filler question. For a longer look at how polynucleotides behave in the skin, see our polynucleotide skin booster guide.

Who should get the injection, and who should wait?

The injection is generally considered for adults who want better texture, hydration or fine-line quality and can accept a few days of small marks. It is not a lift and not a volume treatment, so sagging jowls or deep hollows need a different plan.

It tends to fit people who:

  • notice dull, rough or dehydrated-looking skin that a home routine hasn't changed;
  • have fine lines or crepey texture, including around the eyes (the I version);
  • want a change in skin quality rather than in face shape.

It's usually postponed or reconsidered if you:

  • have a known allergy to fish or salmon-derived products, or to any component of the product;
  • have an active infection, cold sore or acne flare where the injections would go;
  • are pregnant or breastfeeding, because data in these groups are limited;
  • take blood thinners, which raise the chance of bruising, or have an autoimmune condition, both of which need discussion with the doctor first;
  • have an event, photos or a flight within the next couple of days.

On the evidence: a 2025 systematic review of polynucleotides in esthetic medicine, published in the Journal of Cosmetic Dermatology, found encouraging results for skin quality but noted that most studies were small and called for larger controlled trials. Promising and still being studied is a fair summary of where PN stands. If pitted scarring is your main concern, our acne scar treatment guide covers options aimed at scars more directly. If uneven tone is the issue, the skin whitening guide explains what clinics can and can't do for pigmentation.

Book a consultation

Send us your question or a photo on WhatsApp and we will reply in English.

Send a daylight skin photo on WhatsApp →

What one visit involves

A visit covers a consultation with the doctor, the injection itself and aftercare instructions. HERA's site describes consultation and treatment in a single visit, which matters when you only have a few days in Seoul, and consultations run with an English interpreter.

  1. Consultation. You describe what bothers you, the doctor examines the skin in person, and the interpreter makes sure questions in both directions are understood. The version and the number of injection points are decided here.
  2. Preparation. The skin is cleansed. A topical numbing cream is commonly applied before skin booster injections, since the many small injections sting.
  3. Injection. PN is placed in tiny amounts across the treated area, which is why you leave with a pattern of small bumps.
  4. Aftercare. You get instructions for the next few days: what to avoid, and which signs are a reason to get in touch.

According to HERA's site, every treatment is planned and performed by the clinic's doctors, and single-use needles and sterilized instruments are used for every patient. At any clinic, it's reasonable to ask to see the product box and its label before it's opened.

Side effects and recovery: what's normal after the injection?

Small raised bumps at the injection points are expected and usually flatten within a day or so. Mild redness can last a little longer, and a bruise, if one appears, may take about a week to fade. How quickly each settles varies from person to person.

  • Same day. Bumps and pinpoint marks across the treated area. Common advice is to skip makeup, sauna, alcohol and hard workouts for the rest of the day.
  • Around day 3. Most bumps have flattened. Some people still have faint redness or a small bruise, which makeup can usually cover by now.
  • Around day 7. Any bruise is usually fading. Changes in texture, if they come, build gradually over the following weeks rather than overnight.

Less common are swelling that lasts several days and small lumps you can feel under the skin. Rarely, infection or an allergic reaction can occur. Increasing pain, heat, spreading redness or pus are reasons to contact the clinic or see a doctor promptly, wherever you are.

Before your flight

Avoid booking the injection for the day before you fly home. Plan it early in the trip, so that if a bruise or a reaction appears, you're still in Seoul and close to the doctor who treated you.

Visiting HERA in Gangnam

HERA Clinic is at 4F, 9 Seocho-daero 73-gil, Seocho-gu, Seoul, about 3 minutes from Gangnam Station. Hours are Monday and Friday 10:00–20:00, Tuesday to Thursday 10:00–19:00 and Saturday 10:00–17:00, with a lunch break from 13:00 to 14:00. The clinic is closed on Sundays and public holidays.

The clinic is registered with Korea's Ministry of Health and Welfare as a Foreign Patient Attraction Medical Institution, and its medical team is three plastic surgeons. I'm Dr. Kim Jong Seon, the director, a board member of the Korean Society of Aesthetic Surgery (KSAS) and of the International Petit Medical Society. The HERA Clinic home page lists the full treatment menu.

If you can't tell whether your concern is a jar problem or a syringe problem, send one daylight photo of the area, without makeup, on WhatsApp with a line about what bothers you. The doctor reviews it; the final plan is made in person. If the answer is the serum on your shopping list, that's a good outcome too.

FAQ

Frequently asked questions

  • Q1Is Rejuran a Korean brand?
    Yes. Rejuran is a Korean brand, and in Seoul you'll find both its cosmetic line in shops and its injectable versions in clinics. The two share the PN ingredient family but are different products used in different ways.
  • Q2Can I go sightseeing after a Rejuran injection?
    Usually, yes. The small bumps are visible for about a day, so many people choose a low-key afternoon. Skip sauna, alcohol and hard workouts on the day itself.
  • Q3How many Rejuran sessions do I need?
    Injectable PN is commonly planned as a short series spaced a few weeks apart, and the doctor sets the number after examining your skin. A single session during one trip is possible, but changes from one session may be modest and vary by person.
  • Q4Does a Rejuran injection hurt?
    Most people describe it as stinging rather than painful. A topical numbing cream is commonly used first, and Rejuran HB is commonly described as containing a local anaesthetic. The thin skin around the eyes tends to feel more sensitive.
  • Q5Will I see a change before I fly home?
    Probably not much in the first few days. What you'll mostly see early on is the bumps settling. Changes in texture, if they come, build gradually over the following weeks, and results vary between individuals.

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Say goodbye to vertical neck wrinkles—WITHOUT surgery! 🙅‍♀️✨ Vertical neck lines used to be the hardest to treat, often needing a surgical neck lift. But the trend has changed NOW Introducing the CaHA Skin Booster treatment! 💉 By spreading diluted calcium filler evenly under the vertical folds, we stimulate your skin to regain its firmness and bounce naturally. Perfect for ✅ Loss of skin elasticity ✅ Deep vertical neck bands ✅ Those wanting surgical results without the downtime The future of neck rejuvenation is here at Gangnam Hera. 🤍

@gnheraclinic_en

Even without lifting, your look can change this much. By adding only the necessary amount of filler to the temples, lateral cheeks, and chin, and combining chin Botox with Juvelook Eye, we refined the overall balance. Not to look unnaturally younger, but natural and smooth. This is a case that shows how much of a difference filler alone can make. 📩 For consultations and appointments, please contact us via DM or WhatsApp. * Results may vary by individual.TikTok

Even without lifting, your look can change this much. By adding only the necessary amount of filler to the temples, lateral cheeks, and chin, and combining chin Botox with Juvelook Eye, we refined the overall balance. Not to look unnaturally younger, but natural and smooth. This is a case that shows how much of a difference filler alone can make. 📩 For consultations and appointments, please contact us via DM or WhatsApp. * Results may vary by individual.

@gnheraclinic_en

As we enter our 40s, many people start to notice: ✔️ Looser facial contours ✔️ A double chin ✔️ Deeper neck lines Improvement isn’t only about “lifting.” By reducing excess volume, refining the contours, and adding volume only where needed, the overall appearance can change significantly. This case combines: Ultherapy, fat-dissolving injections, Botox, and filler. Not to look unnaturally younger, but to look natural, clean, and refined. We offer facial contouring tailored for your 40s, with a balanced and thoughtful approach. For inquiries and appointments, please contact us via DM or WhatsApp.TikTok

As we enter our 40s, many people start to notice: ✔️ Looser facial contours ✔️ A double chin ✔️ Deeper neck lines Improvement isn’t only about “lifting.” By reducing excess volume, refining the contours, and adding volume only where needed, the overall appearance can change significantly. This case combines: Ultherapy, fat-dissolving injections, Botox, and filler. Not to look unnaturally younger, but to look natural, clean, and refined. We offer facial contouring tailored for your 40s, with a balanced and thoughtful approach. For inquiries and appointments, please contact us via DM or WhatsApp.

@gnheraclinic_en

A special New Year message from the doctors at HERA. 💌 May your 2026 be as bright and glowing as the skin you’ve always dreamed of. We are so grateful to be part of your beauty journey. Stop the screen to reveal the blessing waiting for you! 🧧✨ Wishing you a year of overflowing happiness and health. Happy New Year! 🎊TikTok

A special New Year message from the doctors at HERA. 💌 May your 2026 be as bright and glowing as the skin you’ve always dreamed of. We are so grateful to be part of your beauty journey. Stop the screen to reveal the blessing waiting for you! 🧧✨ Wishing you a year of overflowing happiness and health. Happy New Year! 🎊

@gnheraclinic_en

Body Ultherapy? 👀 Meet Sizer. 📢FDA-approved for belly fat reduction. Goes deeper. Works better. Sizer + fat-dissolving injections = 🔥TikTok

Body Ultherapy? 👀 Meet Sizer. 📢FDA-approved for belly fat reduction. Goes deeper. Works better. Sizer + fat-dissolving injections = 🔥

@gnheraclinic_en

On YouTube

YouTube Shorts

Quick, honest answers from our doctors — tap any short to play.

The Director is totally hooked on *The Man Living with the King*! (Warning: Reality Check) #Shorts

@GangNamHERA

What procedure did a plastic surgeon father allow only for his daughter? #Shorts

@GangNamHERA

The ultimate 1+1 thread lift? #Shorts

@GangNamHERA

The ultimate procedure for brides-to-be✨ Do it exactly one month in advance! #Shorts

@GangNamHERA

Scars that stand out more in summer, what's the key to fixing them? #Shorts

@GangNamHERA

A procedure the director would never have his family do #Shorts

@GangNamHERA

A salon owner doing everything from memes to challenges lol let’s hit the algorithm🔥 #Shorts

@GangNamHERA

Um... do you think I can win the lottery? #Shorts

@GangNamHERA

Can I Get Skin Treatments While Pregnant? 🤰✨#Shorts

@GangNamHERA

Eyelid filler consultation... If you go in the morning, you'll fail! #shorts

@GangNamHERA

Celebrity Procedures Explained by a Plastic Surgeon with 20 Years of Experience✨ #Shorts

@GangNamHERA

Plastic surgeons' reactions to new words these days #shorts

@GangNamHERA

Your medical team

A Medical Team That Sees You Through, Start to Finish

Board-certified specialists who treat every patient like family — the same doctor guides you from your first consultation to your final result, aiming for natural beauty with minimal need for revision.

  • Dr. Kim Jong Seon

    Dr. Kim Jong Seon

    “I am a doctor you can trust, dedicated to enhancing your natural beauty.”

    Career & Credentials

    • Director, Gangnam HERA Plastic Surgery Clinic
    • Board Member, Korean Society of Aesthetic Surgery (KSAS)

    +9 more

  • Dr. Lee Jong Hoon

    Dr. Lee Jong Hoon

    “I dedicate myself to achieving the best results with minimal need for revision.”

    Career & Credentials

    • Co-author, LIFTINGOLOGY: Science and Clinical Practice in Aesthetic Medicine
    • Recipient, Minister of Health and Welfare Award for Outstanding Contribution to National Health Improvement

    +11 more

Let's talk

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  • English interpreter on-site
  • MOHW-registered clinic
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