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Few K-beauty treatments have travelled as far as the polynucleotide skin booster. If you have searched for "Rejuran", "salmon DNA skin booster" or "PDRN injection" before a trip to Seoul, this guide is for you. At HERA Clinic in Gangnam, every international patient is supported by an on-site English interpreter and pays the same price as local patients β so you can focus on your skin, not the logistics.
What is a polynucleotide skin booster?
A polynucleotide (PN) skin booster is an injectable treatment that works from within the skin rather than on its surface. The active ingredient is a purified polynucleotide derived from salmon DNA β which is why you will often see it described as a "salmon DNA skin booster". Delivered through fine micro-injections into the upper skin, it helps create a healthier environment for the skin to repair itself, supporting hydration, texture and resilience over time.
You may also see the closely related term PDRN. PDRN (polydeoxyribonucleotide) and PN (polynucleotide) come from the same salmon-derived family; PN chains are longer, and both are used in regenerative skin boosters. Rejuran β one of the most recognised names, sometimes called "Rejuran Healer" β belongs to this polynucleotide category.
Mechanistically, the appeal of polynucleotides lies in where they act. Rather than sitting in the skin as a volumising gel, the polynucleotide fragments are gradually broken down in the dermis, and this process is thought to help create conditions in which resident skin cells (fibroblasts) can work more comfortably β supporting the skin's own moisture-binding and repair activity. This is why the category is described as a "skin booster" or "regenerative" treatment rather than a filler: the goal is a healthier skin environment over weeks, not an instant change in shape. Reported outcomes still vary between individuals, and published clinical data continues to evolve, so a HERA doctor frames realistic expectations for your skin during consultation.
Rejuran, Rejuran HB, Rejuran I & Revive β HERA's line-up
Healthy skin renewal needs both deep moisture and genuine repair, so HERA's Hydration & Repair program layers regenerative boosters to your skin:
- Rejuran β restores the dermal environment with salmon-derived polynucleotide (PN).
- Rejuran HB β adds hyaluronic acid to lock in lasting moisture for dry, tight skin.
- Rejuran I β refines delicate zones such as fine lines and thin under-eye skin.
- Revive β works deeper in the dermis to help rebuild firmness and glow.
Each protocol is matched to your skin thickness and concern, rather than applied as a one-size-fits-all shot. For pores and depressed acne scars, HERA more often pairs collagen stimulation in the separate Pores & Acne Scars program; your doctor will advise which path suits your goals.
Who is it for?
A polynucleotide booster is popular with patients who want healthier-looking skin quality rather than a change in facial shape. It is often considered for:
- Dull, dehydrated or chronically tight skin.
- Recovery support after lasers, peeling or other intensive treatments.
- Fine wrinkles or thin, fragile skin around the eyes.
- Early loss of elasticity and skin density.
- Anyone seeking gradual, natural improvement in skin strength and hydration.
Sessions, results and downtime
Because regeneration builds over time, a course of roughly 3β4 sessions spaced about 3β4 weeks apart is commonly recommended, followed by periodic maintenance. Skin often feels more hydrated within days, with texture and firmness improving over the following weeks.
The staggered schedule is not arbitrary. Because the effect depends on a biological repair response rather than an instantly-visible product, spacing sessions three to four weeks apart gives the skin time to respond between visits, and the cumulative course is what most patients notice β first as improved hydration and comfort, later as steadier texture and firmness. Maintenance intervals are then set individually, because skin quality, age and lifestyle all influence how long results hold.
Rejuran downtime is usually minimal. Mild redness, tiny injection bumps or slight swelling may appear and typically settle within 1β3 days, and most people return to daily life right away. Individual responses differ, so your doctor will share aftercare suited to your skin.
PRP vs Rejuran vs filler
These treatments are easy to confuse, so here is a simple comparison:
| Treatment | Main source | What it targets |
|---|---|---|
| Polynucleotide booster (Rejuran) | Purified salmon-derived polynucleotide | Skin repair environment, hydration, texture, resilience |
| PRP | Growth factors from your own blood | Skin rejuvenation using your body's own components |
| Filler | Hyaluronic acid | Volume and contour, not skin quality |
In short, PRP vs Rejuran is a question of source and mechanism rather than "better or worse", while a booster vs filler is a question of skin quality vs volume. The right choice depends on your skin, goals and medical history β assessed during your consultation.
How much does a skin booster cost in Korea?
Skin booster pricing in Korea depends on the specific formulation (Rejuran, Rejuran HB, Rejuran I or Revive), the number of sessions in your course, and the areas treated β so a precise skin booster Korea price is best confirmed after a proper consultation rather than from a single online figure. What we can promise at HERA is transparency: international patients pay the same price as local patients, with no foreigner markup, and your plan is explained clearly before anything begins.
What a session at HERA looks like
- Consultation & skin analysis β a HERA doctor assesses hydration, density and your target areas.
- Cleansing & numbing β makeup is removed and topical anaesthetic (with cooling if needed) is applied for comfort.
- Booster injection β the matched Rejuran or Revive formulation is delivered with a fine micro multi-shot technique at the ideal depth.
- Soothing & aftercare β calming care settles the skin, and hydration and sun-care guidance is provided to support regeneration.
Visiting HERA in Gangnam
For international patients, the practical side of a Seoul trip matters as much as the treatment itself. HERA is located in Gangnam, central Seoul, and structures each visit so that language and logistics never get in the way of your care.
- Enquiry & booking β you can reach the English-speaking team ahead of your trip to share your concerns and photos, receive general guidance, and reserve a consultation slot that fits your travel dates.
- On-site English interpretation β an interpreter supports your consultation, treatment and aftercare explanation, so you understand each step and can ask questions freely.
- Same price for everyone β international patients pay the same price as local patients, with no foreigner markup, and your plan is explained in full before anything begins.
- Payment β accepted methods and any deposit terms are confirmed by the team in advance so there are no surprises on the day.
How long to stay: a single polynucleotide booster session is short and downtime is usually minimal, so many visitors fit it around sightseeing. If you are planning a full 3β4 session course, most of it happens after you return home; discuss with your doctor whether to start the first session in Seoul and continue locally, or to concentrate visits during a longer stay.
Aftercare while travelling: because reactions are typically limited to brief redness or tiny injection bumps for 1β3 days, aftercare on a trip is mostly gentle β keep the area clean, avoid heavy heat (saunas, intense sun), stay hydrated and follow the sun-care guidance you are given. Your doctor will flag anything to watch for and how to reach the clinic if you have questions after you leave.
Combining treatments: many travellers pair a booster with other skin-quality or lifting procedures during the same visit. Whether treatments can safely be combined on one day depends on your skin and the specific procedures, so this is planned during your consultation rather than assumed β see the Hydration & Repair program or the Pores & Acne Scars program for how HERA layers regenerative care.
Frequently asked questions
Is a polynucleotide booster the same as filler?
No. A polynucleotide booster such as Rejuran is injected shallowly to hydrate and regenerate the skin from within, improving texture and resilience rather than adding volume or reshaping contours. Filler restores volume and shape, and many patients combine the two for different goals.
How many sessions will I need, and when will I see results?
Around 3β4 sessions spaced 3β4 weeks apart is common, as regeneration builds gradually. Skin often feels more hydrated within days, with texture and firmness improving over several weeks. Individual results vary and your doctor tailors the plan.
What is the downtime?
Usually minimal β mild redness or tiny injection bumps typically fade within 1β3 days, and most people return to daily life right away.
PRP vs Rejuran β which is better?
They work differently rather than one being simply "better". PRP uses growth factors from your own blood; Rejuran uses purified salmon-derived polynucleotide to support the skin's repair environment. Your doctor helps you choose based on your skin and goals.
Will I be charged more as a foreigner?
No. HERA charges international patients the same price as local patients, and an English interpreter supports your visit.
This article is general information, not medical advice; suitability, results and downtime vary between individuals. To explore a plan for your skin, our English-speaking team is one message away β see the Hydration & Repair program or browse all skin-regeneration boosters.
FAQ
Frequently asked questions
Q1Is a polynucleotide booster the same as filler?
No. A polynucleotide skin booster such as Rejuran is injected shallowly to hydrate and regenerate the skin from within, improving texture and resilience rather than adding volume or reshaping contours. Filler restores volume and shape. Many patients combine the two for different goals.Q2How many Rejuran sessions will I need and when will I see results?
A course of roughly 3β4 sessions spaced about 3β4 weeks apart is commonly recommended, because regeneration builds over time. Skin often feels more hydrated within days, while texture and firmness continue to improve over several weeks. Individual results vary and your doctor tailors the plan to your skin.Q3What is the downtime after a Rejuran or polynucleotide booster?
Downtime is usually minimal. Mild redness, tiny injection bumps, or slight swelling may appear and typically settle within 1β3 days. Most people return to daily life right away, though your doctor will share personalised aftercare.Q4PRP vs Rejuran β which is better?
They work differently. PRP uses growth factors from your own blood, while a polynucleotide booster like Rejuran uses purified salmon-derived polynucleotide to support the skin's repair environment. The best choice depends on your skin, goals and medical history, which a HERA doctor will assess during consultation.Q5How much does a skin booster cost in Korea, and are foreigners charged more?
Pricing depends on the formulation, the number of sessions and the areas treated, so a precise quote is shared after your consultation. At HERA Clinic, international patients pay the same price as local patients β there is no foreigner markup β and an English interpreter supports your visit.
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A Medical Team That Sees You Through, Start to Finish
Board-certified specialists who treat every patient like family β the same doctor guides you from your first consultation to your final result, aiming for natural beauty with minimal need for revision.
Dr. Kim Jong Seon
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- Seoul National University Graduate School of Public Health Executive Course,
- Former Director of Pladen Plastic Surgery
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Dr. Lee Jong Hoon
βI dedicate myself to achieving the best results with minimal need for revision.β
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- Seoul National University Graduate School of Public Health Executive Course,
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