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Polynucleotide Skin Booster in Korea: The Rejuran Guide

Gangnam HERA9 min readLast updated
Polynucleotide Skin Booster in Korea: The Rejuran Guide

Few K-beauty treatments have travelled as far as the polynucleotide skin booster. If you have searched for "Rejuran", "salmon DNA skin booster" or "PDRN injection" before a trip to Seoul, this guide is for you. At Gangnam HERA in Seoul, every international patient is supported by an on-site English interpreter and pays the same price as local patients β€” so you can focus on your skin, not the logistics.

What is a polynucleotide skin booster?

A polynucleotide (PN) skin booster is an injectable treatment that works from within the skin rather than on its surface. The active ingredient is a purified polynucleotide derived from salmon DNA β€” which is why you will often see it described as a "salmon DNA skin booster". Delivered through fine micro-injections into the upper skin, it helps create a healthier environment for the skin to repair itself, supporting hydration, texture and resilience over time.

You may also see the closely related term PDRN. PDRN (polydeoxyribonucleotide) and PN (polynucleotide) come from the same salmon-derived family; PN chains are longer, and both are used in regenerative skin boosters. Rejuran β€” one of the most recognised names, sometimes called "Rejuran Healer" β€” belongs to this polynucleotide category.

Mechanistically, the appeal of polynucleotides lies in where they act. Rather than sitting in the skin as a volumising gel, the polynucleotide fragments are gradually broken down in the dermis, and this process is thought to help create conditions in which resident skin cells (fibroblasts) can work more comfortably β€” supporting the skin's own moisture-binding and repair activity. This is why the category is described as a "skin booster" or "regenerative" treatment rather than a filler: the goal is a healthier skin environment over weeks, not an instant change in shape. Reported outcomes still vary between individuals, and published clinical data continues to evolve, so a HERA doctor frames realistic expectations for your skin during consultation.

Polynucleotide skin booster performed in Gangnam HERA's treatment room in Gangnam, Seoul
Polynucleotide skin booster is performed by licensed physicians in HERA's Gangnam clinic.

Rejuran, Rejuran HB & Rejuran I β€” HERA's line-up

Healthy skin renewal needs both deep moisture and genuine repair, so HERA's Hydration & Repair program layers regenerative boosters to your skin:

  • Rejuran β€” restores the dermal environment with salmon-derived polynucleotide (PN).
  • Rejuran HB β€” adds hyaluronic acid to lock in lasting moisture for dry, tight skin.
  • Rejuran I β€” refines delicate zones such as fine lines and thin under-eye skin.

Each protocol is matched to your skin thickness and concern, rather than applied as a one-size-fits-all shot. For pores and depressed acne scars, HERA more often pairs collagen stimulation in the separate Pores & Acne Scars program; your doctor will advise which path suits your goals.

Who is it for?

A polynucleotide booster is popular with patients who want healthier-looking skin quality rather than a change in facial shape. It is often considered for:

  • Dull, dehydrated or chronically tight skin.
  • Recovery support after lasers, peeling or other intensive treatments.
  • Fine wrinkles or thin, fragile skin around the eyes.
  • Early loss of elasticity and skin density.
  • Anyone seeking gradual, natural improvement in skin strength and hydration.
Gangnam HERA interior in Gangnam, Seoul
Gangnam HERA in Seoul β€” same price for local and international patients, English interpreter on-site.

Sessions, results and downtime

Because regeneration builds over time, a course of roughly 3–4 sessions spaced about 3–4 weeks apart is commonly recommended, followed by periodic maintenance. Skin often feels more hydrated within days, with texture and firmness improving over the following weeks.

The staggered schedule is not arbitrary. Because the effect depends on a biological repair response rather than an instantly-visible product, spacing sessions three to four weeks apart gives the skin time to respond between visits, and the cumulative course is what most patients notice β€” first as improved hydration and comfort, later as steadier texture and firmness. Maintenance intervals are then set individually, because skin quality, age and lifestyle all influence how long results hold.

Rejuran downtime is usually minimal. Mild redness, tiny injection bumps or slight swelling may appear and typically settle within 1–3 days, and most people return to daily life right away. Individual responses differ, so your doctor will share aftercare suited to your skin.

PRP vs Rejuran vs filler

These treatments are easy to confuse, so here is a simple comparison:

Treatment Main source What it targets
Polynucleotide booster (Rejuran) Purified salmon-derived polynucleotide Skin repair environment, hydration, texture, resilience
PRP Growth factors from your own blood Skin rejuvenation using your body's own components
Filler Hyaluronic acid Volume and contour, not skin quality

In short, PRP vs Rejuran is a question of source and mechanism rather than "better or worse", while a booster vs filler is a question of skin quality vs volume. The right choice depends on your skin, goals and medical history β€” assessed during your consultation.

Consultation for Polynucleotide skin booster at Gangnam HERA Seoul
Every plan starts with an in-person consultation with a licensed physician.

How much does a skin booster cost in Korea?

Skin booster pricing in Korea depends on the specific formulation (Rejuran, Rejuran HB or Rejuran I), the number of sessions in your course, and the areas treated β€” so a precise skin booster Korea price is best confirmed after a proper consultation rather than from a single online figure. What we can promise at HERA is transparency: international patients pay the same price as local patients, with no foreigner markup, and your plan is explained clearly before anything begins.

What's included at HERA β€” and the same-price policy

When you receive a Rejuran skin booster treatment in Korea at HERA, the plan is put in writing before anything begins. A typical course includes:

  • An in-person skin assessment with a licensed physician.
  • The agreed number of sessions and the specific Rejuran formula matched to your skin.
  • Numbing and a comfort-focused injection technique.
  • Written aftercare and follow-up guidance, with our team reachable if questions come up.

On pricing: we do not print per-session or per-vial numbers online, because the honest "how much is Rejuran in Korea" answer depends on how many sessions your skin actually needs and which formula is used. What we can promise is that international and local patients pay exactly the same price β€” there is no foreigner markup β€” and you will receive a clear, itemised written estimate after your consultation, before you commit. If you message us in advance, our English-speaking team can walk you through what a typical course involves for your concern.

Trust: doctor-led care and genuine product

Skin boosters are injectables, and the two things that matter most are who injects and what is injected. At HERA, Rejuran is administered by licensed physicians β€” not delegated β€” and every product follows our genuine-handling protocol: sealed products opened in front of you where appropriate, with serial and record-keeping so you know exactly what went into your skin.

Explore our full range of skin regeneration boosters to see how Rejuran sits alongside other options we offer.

What a session at HERA looks like

  • Consultation & skin analysis β€” a HERA doctor assesses hydration, density and your target areas.
  • Cleansing & numbing β€” makeup is removed and topical anaesthetic (with cooling if needed) is applied for comfort.
  • Booster injection β€” the matched Rejuran formulation is delivered with a fine micro multi-shot technique at the ideal depth.
  • Soothing & aftercare β€” calming care settles the skin, and hydration and sun-care guidance is provided to support regeneration.

Visiting HERA in Gangnam

For international patients, the practical side of a Seoul trip matters as much as the treatment itself. HERA is located in Gangnam, central Seoul, and structures each visit so that language and logistics never get in the way of your care.

  • Enquiry & booking β€” you can reach the English-speaking team ahead of your trip to share your concerns and photos, receive general guidance, and reserve a consultation slot that fits your travel dates.
  • On-site English interpretation β€” an interpreter supports your consultation, treatment and aftercare explanation, so you understand each step and can ask questions freely.
  • Same price for everyone β€” international patients pay the same price as local patients, with no foreigner markup, and your plan is explained in full before anything begins.
  • Payment β€” accepted methods and any deposit terms are confirmed by the team in advance so there are no surprises on the day.

How long to stay: a single polynucleotide booster session is short and downtime is usually minimal, so many visitors fit it around sightseeing. If you are planning a full 3–4 session course, most of it happens after you return home; discuss with your doctor whether to start the first session in Seoul and continue locally, or to concentrate visits during a longer stay.

Aftercare while travelling: because reactions are typically limited to brief redness or tiny injection bumps for 1–3 days, aftercare on a trip is mostly gentle β€” keep the area clean, avoid heavy heat (saunas, intense sun), stay hydrated and follow the sun-care guidance you are given. Your doctor will flag anything to watch for and how to reach the clinic if you have questions after you leave.

Combining treatments: many travellers pair a booster with other skin-quality or lifting procedures during the same visit. Whether treatments can safely be combined on one day depends on your skin and the specific procedures, so this is planned during your consultation rather than assumed β€” see the Hydration & Repair program or the Pores & Acne Scars program for how HERA layers regenerative care.

Frequently asked questions

Is a polynucleotide booster the same as filler?

No. A polynucleotide booster such as Rejuran is injected shallowly to hydrate and regenerate the skin from within, improving texture and resilience rather than adding volume or reshaping contours. Filler restores volume and shape, and many patients combine the two for different goals.

How many sessions will I need, and when will I see results?

Around 3–4 sessions spaced 3–4 weeks apart is common, as regeneration builds gradually. Skin often feels more hydrated within days, with texture and firmness improving over several weeks. Individual results vary and your doctor tailors the plan.

What is the downtime?

Usually minimal β€” mild redness or tiny injection bumps typically fade within 1–3 days, and most people return to daily life right away.

PRP vs Rejuran β€” which is better?

They work differently rather than one being simply "better". PRP uses growth factors from your own blood; Rejuran uses purified salmon-derived polynucleotide to support the skin's repair environment. Your doctor helps you choose based on your skin and goals.

Will I be charged more as a foreigner?

No. HERA charges international patients the same price as local patients, and an English interpreter supports your visit.

If you have seen Rejuran sold as a skincare jar online, the article on Rejuran skincare jar versus syringe explains how the two differ.

This article is general information, not medical advice; suitability, results and downtime vary between individuals. To explore a plan for your skin, our English-speaking team is one message away β€” see the Hydration & Repair program or browse all skin-regeneration boosters.

FAQ

Frequently asked questions

  • Q1Is a polynucleotide booster the same as filler?
    No. A polynucleotide skin booster such as Rejuran is injected shallowly to hydrate and regenerate the skin from within, improving texture and resilience rather than adding volume or reshaping contours. Filler restores volume and shape. Many patients combine the two for different goals.
  • Q2How many Rejuran sessions will I need and when will I see results?
    A course of roughly 3–4 sessions spaced about 3–4 weeks apart is commonly recommended, because regeneration builds over time. Skin often feels more hydrated within days, while texture and firmness continue to improve over several weeks. Individual results vary and your doctor tailors the plan to your skin.
  • Q3What is the downtime after a Rejuran or polynucleotide booster?
    Downtime is usually minimal. Mild redness, tiny injection bumps, or slight swelling may appear and typically settle within 1–3 days. Most people return to daily life right away, though your doctor will share personalised aftercare.
  • Q4PRP vs Rejuran β€” which is better?
    They work differently. PRP uses growth factors from your own blood, while a polynucleotide booster like Rejuran uses purified salmon-derived polynucleotide to support the skin's repair environment. The best choice depends on your skin, goals and medical history, which a HERA doctor will assess during consultation.
  • Q5How much does a skin booster cost in Korea, and are foreigners charged more?
    Pricing depends on the formulation, the number of sessions and the areas treated, so a precise quote is shared after your consultation. At Gangnam HERA, international patients pay the same price as local patients β€” there is no foreigner markup β€” and an English interpreter supports your visit.
  • Q6How much is Rejuran in Korea?
    We don't publish per-session or per-vial prices, because the honest cost depends on how many sessions your skin needs and which Rejuran formula is used. At HERA, local and international patients pay the same price, and you receive a clear written estimate after your in-person consultation, before you commit.
  • Q7How many Rejuran sessions will I need?
    Most people do a short course of a few sessions spaced two to four weeks apart, as results build gradually. The exact number is decided by a physician based on your skin and goals β€” a single session is rarely a complete answer.
  • Q8Is Rejuran the same as filler?
    No. A Rejuran injection is a PDRN skin booster focused on skin repair, hydration and texture β€” not volume or contour. If you want to reshape the chin, cheeks or jawline, that's a filler conversation and we'll point you to the right option.

Nazanin Kondori

Oct 2026

Received Botox from Dr Hoon on the forehead and crow feet, Dr Hoon was very attentive and talked me through the procedure and listening to my expectations of a natural look - the clinic is very clean, staff are helpful and attentive - overall a very good experience, highly recommended

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Niroy Wilkes

Oct 2026

Dr. Han Jin Yi, Jasmine and the team were so amazing. My appointment was on time. I had a skin analysis and a very thorough consultation. The translator, Jasmine was just wonderful and the Dr. too. Everyone was very professional β€”very communicative throughout the entire procedure. Numbing was fully adequate and very little pain during the procedure I felt very well taken care of thank you so much, HERA.

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Carine Na Koreia

Oct 2026

I visited Gangnam Hera Lifting & Filler Clinic β€” an experience that only Korea can offer! πŸ‡°πŸ‡·βœ¨ A modern treatment with real, visible results for the skin. I tried Tenthera 800 Lines Procedure: Face + Interior with Dr. Lee Jong Hoon, and it was such an interesting experience to see how advanced Korean aesthetic treatments have become. I’ve been living in Korea for over five years, and I’m always looking for the best aesthetic treatments, impeccable service, and highly professional care. Having English interpretation available also makes the whole experience much more comfortable and ensures a clear understanding of every step of the treatment.

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Emmey Chefero

Oct 2026

I visited Gangman Hera Clinic and received lip filler from Dr. Kim Jong Seon. I was greeted by Jasmine when we first arrived and she assisted in translating the entire visit for us. This clinic is so clean, professional, and every staff member was kind and welcoming. I felt safe and thoroughly enjoyed the treatment process as well as my results. We had a full consultation to answer any questions and concerns we had. I would recommend this clinic to anyone visiting Seoul looking to get a luxury treatment.

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ryleigh stearns-nixon

Oct 2026

I got my lip filler done and I’m in love!!! the doctor and staff are so helpful!! Foreigners are very welcome here. I had a lovely experience would definitely recommend!!

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Maria Lammy

Oct 2026

Dr. Kim Jong Seon was so patient and knowledgeable. He gave me expert recommendations and took great care for the Botox treatment. All the staff were so polite and helpful. Very easy English service!

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Su May Yap

Sep 2026

Excellent service from start to finish with interpreter Jasmine and treatment with Dr Han Jin Yi. They explained everything in detail even during the treatments each step. Thank you!

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Jarie Balbedina

Sep 2026

I went to Hera Clinic to get Titanium Lifting for my skin concerns including developing wrinkles and overall contouring. My doctor was Dr. Lee Jong Hoon and he was very kind and easy to talk to. He recommended the appropriate kJ for my skin condition after a thorough consultation. The procedure itself also went well, although I did felt a bit more heat than I expected. Overall, my experience was very comfortableβ€”also thanks to all the nice staff and interpreter who assisted me throughout my visit~

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On YouTube

Hear it from the doctors before you fly

Our doctors explain HERA's main treatments, lifting, filler and skin boosters, on camera, so you know who you are meeting and how they think before you land in Seoul.

Subscribe on YouTube

Korean audio Β· auto-translated captions available on YouTube

16 videos

  • 6:24Filler

    Dr. Kim and Dr. Lee sort out how fillers, collagen injections and skin boosters differ, and which concern each one is for.

    Dr. Jong Β· Dr. Jong

  • 7:36Clinic & doctors

    HERA podcast ep. 3 β€” Dr. Kim and Dr. Lee look at the same face and explain the treatments they would choose, and why.

    Dr. Jong Β· Dr. Jong

  • 8:07Lifting

    What APTOS threads are, who they are recommended for, and a real patient's treatment and before-and-after.

    Dr. Jong

  • 5:44Lifting

    How APTOS compares with other lifting threads, what recovery is like and how long results last.

    Dr. Jong Β· Dr. Jong

  • 4:20Filler

    Dr. Kim shows how injection technique changes with the amount of filler, and how filler dissolves.

    Dr. Jong

  • 5:50Filler

    What a hollow upper eyelid is, filler vs fat grafting, how long it lasts and what to watch for.

    Dr. Jong

  • 5:20Filler

    Dr. Kim breaks down lip proportion, volume and mouth corners using well-known Korean celebrities' lips as examples.

    Dr. Jong

  • 5:39Skin & boosters

    Hydration, pores, breakouts or tone β€” matching the skin booster to what your skin actually needs.

    Dr. Jong

  • 6:05Skin & boosters

    Dr. Lee explains how Lituo and CaHA work, how they are injected and how often.

    Dr. Jong

  • 5:00Skin & boosters

    What Juvelook Eye is, what it is used for, how many sessions it takes and how long it lasts.

    Dr. Jong

  • 5:56Lifting

    Why lines form around the eyes, which treatments are combined, and Eye Thermage vs Eye Ulthera.

    Dr. Jong

  • 4:58Lifting

    Why Dr. Lee cares about lifting, and what he looks at first when he sees a patient.

    Dr. Jong

  • 3:30Clinic & doctors

    Dr. Han talks about what matters most in a consultation and the approach behind every treatment.

    Dr. Jin

  • 5:29Skin & boosters

    A tour of HERA's main devices and which skin concern β€” pores, texture or firmness β€” each one helps with.

    Dr. Jong

  • 4:40Clinic & doctors

    Three areas brides care about, recommended treatments, and what still works with a month to go.

    Dr. Jong Β· Dr. Jong

  • 4:39Clinic & doctors

    What an AI skin scan measures β€” wrinkles, pigment, firmness, pores β€” and why a doctor's consultation still matters.

    Dr. Jong Β· Dr. Jong

Shorts

One question, under a minute

All Shorts
  • Each tip reaches a different depth, so the choice depends on the area and your skin.

  • More shots is not automatically better β€” it depends on the area you want treated.

  • Asked to pick three treatments for the same face β€” one doctor picked four.

  • Skin thickness, fat and sagging differ face to face β€” what the doctor checks in a consultation.

  • The difference between the three, explained simply.

  • What Lituo is and the reason behind its reputation.

  • No β€” the right thread depends on your face and the lift you want.

  • What sets MINT threads apart from other lifting threads.

  • A patient shares the concern before lifting and how it felt afterwards.

  • Dr. Lee in under a minute: what a natural lift means to him.

  • A one-minute introduction to Dr. Han.

  • Similar-sounding, different purposes: how to tell them apart.

Visit us

Find Gangnam HERA

In Seocho-gu, Seoul, a three-minute walk from Gangnam Station Exit 9. Tap the map for directions.

Address

4F, 9 Seocho-daero 73-gil, Seocho-gu, Seoul, Republic of Korea

Opening Hours

Tuesday, Wednesday, and Thursday: 10:00 AM – 7:00 PM; Monday, Friday: 10:00 AM – 8:00 PM; Saturday: 10:00 AM – 5:00 PM; Lunch break: 1:00 PM – 2:00 PM; Closed on Sundays and public holidays

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Send us a message. The consultation is free, and our team replies in English.

  • Same price for locals & foreigners
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